Potassium Carbonate → Cyclohexylthiourea

HRID 530413

반응식

HRID 530413 반응식
[CH:1]1([NH:7][C:8]([NH:10]C(=O)C2C=CC=CC=2)=[S:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH:1]1([NH:7][C:8]([NH2:10])=[S:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 895546Benzamide, N-[(cyclohexylamino)thioxomethyl]-

생성물 1

HCID 1471603Cyclohexylthiourea수율 95%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of N-(cyclohexylcarbamothioyl)benzamide (17.1 g, 65.5 mmol) in ethanol was added aqueous potassium carbonate (18.2 g, 132.2 mmol). The mixture was stirred at reflux temperature for 4 h. The organic layer was concentrated to a small volume, after which the product could be collected by filtration, then washed with petroleum ether and dried in vacuo to give the title compound as a white solid (9.8 g, 95% two steps).

후처리

  1. temperatureat reflux temperature for 4 h
  2. concentrationThe organic layer was concentrated to a small volume
  3. filtrationafter which the product could be collected by filtration
  4. washwashed with petroleum ether
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-454e66da240d48e0a01157530c710772
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353089B2

연결된 노트

불러오는 중…