Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Betamethasone Valerate → (2S)-2-((1,1-dimethylethoxycarbonyl)-amino)-3-methyl-butyric acid [11beta,21-dihydroxy-3,20-dioxo-9-fluoro-16beta-methyl-17-valeroyloxy-pregna-1,4-dien-21-yl] ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Betamethasone Valerate | HCID 16533 | — |
| 반응물 | Boc-L-Valine | HCID 83693 | — |
| 반응물 | Ethyl acetate hexane | HCID 21226206 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dioxane methylene chloride | HCID 18626912 | — |
| 생성물 | (2S)-2-((1,1-dimethylethoxycarbonyl)-amino)-3-methyl-butyric acid [11beta,21-dihydroxy-3,20-dioxo-9-fluoro-16beta-methyl-17-valeroyloxy-pregna-1,4-dien-21-yl] ester | HCID 131719966 | 73% |
반응 단계
21 mmol of betamethasone-17-valerate is reacted with 25 mmol of Boc-valine (Boc-Val-OH), 2.5 mmol of 4-dimethylaminopyridine and 27 mmol of dicyclohexylcarbodiimidazole in dichloromethane/dioxane 1:1 analogously to Example 1. Chromatography (1. ethyl acetate/hexane 2:1 and 2. ethyl acetate/hexane 1:1) yields 10.1 g (73%) of pure (2S)-2-((1,1-dimethylethoxycarbonyl)-amino)-3-methyl-butyric acid [11β,21-dihydroxy-3,20-dioxo-9-fluoro-16β-methyl-17-valeroyloxy-pregna -1,4-dien-21-yl] ester as foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05616573 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-4aa3a2e7e4c1420a8ea5ecf484c50303 |
| 출처 메모 | uspto-grants-1997_04 |