N-(2-acetyl-3,5-dimethoxy-phenyl)-4-isopropylthiazole-2-carboxamide → 2-(4-Isopropylthiazol-2-yl)-5,7-dimethoxyquinolin-4-ol
반응식
[C:1]([C:4]1[C:9]([O:10][CH3:11])=[CH:8][C:7]([O:12][CH3:13])=[CH:6][C:5]=1[NH:14][C:15]([C:17]1[S:18][CH:19]=[C:20]([CH:22]([CH3:24])[CH3:23])[N:21]=1)=O)(=[O:3])[CH3:2].C(C1N=C(C2C=C(O)C3C(=CC(OC)=CC=3)N=2)SC=1)(C)C>>[CH:22]([C:20]1[N:21]=[C:17]([C:15]2[CH:2]=[C:1]([OH:3])[C:4]3[C:5](=[CH:6][C:7]([O:12][CH3:13])=[CH:8][C:9]=3[O:10][CH3:11])[N:14]=2)[S:18][CH:19]=1)([CH3:24])[CH3:23]참가 물질
3
실험 절차
Compound 218e was synthesized from compound 217e as a yellow solid in 60% yield, according to the procedures as described for compound 218a. 1H NMR (CDCl3, 400 MHz) δ (ppm) 1.37 (s, 3H), 1.39 (s, 3H), 3.15-3.22 (m, 1H), 3.95 (s, 3H), 4.05 (s, 3H), 6.45 (s, 1H), 7.03 (s, 2H), 7.62 (brs, 1H), 9.55 (s, 1H); MS (ESI, EI+): m/z=331 (MH+).
출처 및 근거
- ORD 기록
- ord-3a72071ca4a547b39695e7c1aa36089c
- 출처 데이터셋
- uspto-grants-2016_05
- DOI