Einecs 211-027-4 → HCID 178431895, 화합물

HRID 530757노트

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HRID 530757 반응식
C[O:2][C:3]1[CH:8]=[C:7]([C:9]2[S:10][CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:13]=2)[N:6]=[C:5]([C:18]2[S:19][CH:20]=[C:21]([CH3:23])[N:22]=2)[CH:4]=1.[Cl-].[NH+]1C=CC=CC=1>O>[CH3:23][C:21]1[N:22]=[C:18]([C:5]2[CH:4]=[C:3]([OH:2])[CH:8]=[C:7]([C:9]3[S:10][CH:11]=[C:12]([C:14]([F:16])([F:15])[F:17])[N:13]=3)[N:6]=2)[S:19][CH:20]=1

참가 물질

4

반응물 2

HCID 69401Einecs 211-027-4HCID 681599974-Methoxy-2-(4-methyl-thiazol-2-yl)-6-(4-trifluoromethyl-thiazol-2-yl)-pyridine

생성물 1

HCID 178431895HCID 178431895, 화합물수율 72%

시약·촉매·용매 1

HCID 962Water용매

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온도
200 °C

실험 절차

A mixture of compound 22 (1.68 mmol) and pyridinium chloride (5 g/mmol) was heated at 200° C. with stirring. After 30 min, the reaction mixture was cooled down to room temperature and H2O was added. The solid was collected, washed with H2O, and dried to give compound 23 as a grey solid in 72% yield. MS (ESI, EI+): m/z=343.85 (MH+

후처리

  1. temperaturethe reaction mixture was cooled down to room temperature
  2. customThe solid was collected
  3. washwashed with H2O
  4. customdried

출처 및 근거

ORD 기록
ord-079761f1ada8495e84cf02a2d56ba7ad
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353100B2

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