Dimethyl Sulfide → DMS bupivacaine

HRID 53078

반응식

HRID 53078 반응식
[CH3:1][S:2][CH3:3].[CH3:4][CH2:5][CH2:6][CH2:7][N:8]1[CH:13]([C:14]([NH:16][C:17]2[C:18]([CH3:24])=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:23])=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9]1>C(O)C>[CH3:1][S:2][CH3:3].[CH3:4][CH2:5][CH2:6][CH2:7][N:8]1[CH:13]([C:14]([NH:16][C:17]2[C:18]([CH3:24])=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:23])=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9]1

참가 물질

4

반응물 2

HCID 1068Dimethyl SulfideHCID 2474Bupivacaine (USAN:INN:BAN)

생성물 1

HCID 131719970DMS bupivacaine

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A uniform mixture of DMS and bupivacaine was formed by combining DMS dissolved in 95% ethanol with bupivacaine dissolved in 95% ethanol. The solution was air-dried under the hood at room temperature until the ethanol evaporated and left behind a well-dispersed mixture of dry crystalline DMS and bupivacaine. The crystalline mixture was pulverized under mortar and pestle and combined with copolymer. The rest of the procedures followed those described for CHP PLAMs. All DMS/bupivacaine PLAMs were synthesized using large bore Teflon® tubing.

후처리

  1. dry with materialThe solution was air-dried under the hood at room temperature until the ethanol
  2. customevaporated
  3. waitleft behind a well-dispersed mixture of dry crystalline DMS and bupivacaine

출처 및 근거

ORD 기록
ord-bea38d61458940fea2cd3e1c387f5571
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05618563

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