Water → (1,3-dimethyl-1H-pyrazol-4-yl)methanamine
반응식
Cl.Cl[C:3]1[N:7]([CH3:8])[N:6]=[C:5]([CH3:9])[C:4]=1[CH2:10][NH2:11].[H-].[H-].[H-].[H-].[Li+].[Al+3].O>C1COCC1>[CH3:8][N:7]1[CH:3]=[C:4]([CH2:10][NH2:11])[C:5]([CH3:9])=[N:6]1참가 물질
5
실험 절차
To a solution of compound 4 (120 mg, 0.61 mmol) in THF (5 mL) was added LAH (43 mg, 3.78 mmol). The resulting mixture was stirred at room temperature overnight. Water was added and the resulting mixture was filtered. Organic layer was separated and then concentrated in vacuum to give a white solid (crude product). LCMS (ESI) m/z=126 (M+H)+.
후처리
- filtrationthe resulting mixture was filtered
- customOrganic layer was separated
- concentrationconcentrated in vacuum
- customto give a white solid (crude product)
출처 및 근거
- ORD 기록
- ord-a602945824aa427dbe9dfe180f482602
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09353104B2
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