Aluminium lithium hydride → Pyrazolo[1,5-a]pyridin-3-ylmethanol
반응식
C(=O)(O)N.[N:5]1[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]2=[C:7]([C:14](OC)=[O:15])[CH:6]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[N:5]1[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]2=[C:7]([CH2:14][OH:15])[CH:6]=1참가 물질
4
실험 절차
A solution of methyl pyrazolo[1,5-a]pyridine-3-carboxylate carbamate (1) (400 mg, 2.10 mmol) in THF (4 mL) was added LiAlH4 (159 mg, 4.20 mmol) at room temperature for 1 h. The reaction mixture was concentrated and 10 mL sat. aq. NaHCO3 was added, extracted with EA (3×10 mL). The organic phase was dried with anhydrous Na2SO4, filtered and concentrated. The residue was purified by Prep-TLC TLC using PE/EtOAc=2/1 to give title compound as oil.
후처리
- concentrationThe reaction mixture was concentrated
- addition10 mL sat. aq. NaHCO3 was added
- extractionextracted with EA (3×10 mL)
- dry with materialThe organic phase was dried with anhydrous Na2SO4
- filtrationfiltered
- concentrationconcentrated
- customThe residue was purified by Prep-TLC TLC
출처 및 근거
- ORD 기록
- ord-616d62769ecc4722abec24a2b02f8f51
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09353104B2
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