Dicyclohexylcarbodiimide → N-(1,1dimethylethoxycarbonyl)glycine N-(2-(-(phenylmethoxy)phenyl)ethyl)amide

HRID 53084

반응식

HRID 53084 반응식
[CH3:1][C:2]([CH3:12])([O:4][C:5]([NH:7][CH2:8][C:9]([OH:11])=O)=[O:6])[CH3:3].[CH:13]1([N:19]=C=NC2CCCCC2)CCCC[CH2:14]1.[C:28]1([CH2:34][O:35][C:36]2[CH:41]=[CH:40][C:39](CCN)=[CH:38][CH:37]=2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>O1CCCC1>[C:28]1([CH2:34][O:35][C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][C:41]=2[CH2:14][CH2:13][NH:19][C:9](=[O:11])[CH2:8][NH:7][C:5]([O:4][C:2]([CH3:1])([CH3:3])[CH3:12])=[O:6])[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

참가 물질

5

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 78288N-(tert-butoxycarbonyl)glycineHCID 2009572-(4-Benzyloxy-phenyl)-ethylamine2회

생성물 1

HCID 54004858N-(1,1dimethylethoxycarbonyl)glycine N-(2-(-(phenylmethoxy)phenyl)ethyl)amide수율 98%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

N-(1,1-Dimethylethoxycarbonyl)glycine N-(2-(4-phenylmethoxy)phenyl)ethyl)amide. N-(1,1-Dimethylethoxycarbonyl)glycine (850 mg, 4.85 mmol) was stirred with dicyclohexylcarbodiimide (1.00 g, 4.85 mmol) and 2-(4-(phenylmethoxy)phenyl)ethylamine (Intermediate C) (1.00 g, 4.4 mmol) in dry tetrahydrofuran (30 mL) for 16 h. The suspension was filtered and the solvent was evaporated from the filtrate under reduced pressure. The residue was dissolved in ethyl acetate and was washed with aqueous sulphuric acid (10%) and with saturated brine. The solution was dried with anhydrous magnesium sulphate and the solvent was evaporated under reduced pressure to give N-(1,1dimethylethoxycarbonyl)glycine N-(2-(-(phenylmethoxy)phenyl)ethyl)amide (1.65 g, 98%).

후처리

  1. filtrationThe suspension was filtered
  2. customthe solvent was evaporated from the filtrate under reduced pressure
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. washwas washed with aqueous sulphuric acid (10%) and with saturated brine
  5. dry with materialThe solution was dried with anhydrous magnesium sulphate
  6. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-6078d91084014e80b9e9af5fb94aaee3
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05618528

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