Benzophenone imine → Methyl 3-(diphenylmethyleneamino)cyclohexanecarboxylate

HRID 530872노트

반응식

HRID 530872 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([C:8]([O:10][CH3:11])=[O:9])[CH2:3]1.[C:12](=N)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>ClCCl>[C:13]1([C:12](=[N:1][CH:2]2[CH2:7][CH2:6][CH2:5][CH:4]([C:8]([O:10][CH3:11])=[O:9])[CH2:3]2)[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 136809Benzophenone imineHCID 13216966Methyl 3-aminocyclohexane-1-carboxylate

생성물 1

HCID 86698247Methyl 3-(diphenylmethyleneamino)cyclohexanecarboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a flask, methyl 3-aminocyclohexanecarboxylate (3.86 g, 19.94 mmol) was dissolved in dichloromethane (80 mL). Benzophenone imine (3.33 mL, 19.94 mmol) was added to the reaction, and the reaction was stirred at room temperature for 24 hrs. Upon completion, the reaction was concentrated and triturated with diethyl ether. The suspension was filtered. This trituration process was done twice. The remaining filtrate was concentrated and progressed to the next step without further purification.

후처리

  1. concentrationUpon completion, the reaction was concentrated
  2. customtriturated with diethyl ether
  3. filtrationThe suspension was filtered
  4. concentrationThe remaining filtrate was concentrated
  5. customprogressed to the next step without further purification

출처 및 근거

ORD 기록
ord-2d8b0faaa1744303bd7cbe87e74a3fe9
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09351965B2

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