Pyridine → HCID 71246821, 화합물

HRID 530907

반응식

HRID 530907 반응식
[I:1][C:2]1[CH:3]=[C:4]([NH2:10])[C:5]([NH:8][CH3:9])=[N:6][CH:7]=1.N1C=CC=CC=1.CCN=C=NCCCN(C)C.[Cl:28][C:29]1[C:30]([C:35](O)=[O:36])=[N:31][CH:32]=[CH:33][CH:34]=1>C1C=CC2N(O)N=NC=2C=1.O>[I:1][C:2]1[CH:3]=[C:4]([NH:10][C:35]([C:30]2[C:29]([Cl:28])=[CH:34][CH:33]=[CH:32][N:31]=2)=[O:36])[C:5]([NH:8][CH3:9])=[N:6][CH:7]=1

참가 물질

7

반응물 4

HCID 1049PyridineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 8246323-Chloropyridine-2-carboxylic acidHCID 67981568HCID 67981568, 화합물

생성물 1

HCID 71246821HCID 71246821, 화합물수율 121.4%

시약·촉매·용매 2

HCID 757711-Hydroxybenzotriazole촉매HCID 962Water용매

실험 절차

To a mixture of 5-iodo-N2-methyl-pyridin-2,3-diamine (1.9 g) and pyridine (6 ml) were added WSC (1.28 g), HOBt (86 mg) and 3-chloro-pyridin-2-carboxylic acid (1.3 g), and the mixture was stirred at room temperature for 9 hours. To this reaction mixture was added water, and the mixture was filtered to collect the precipitated powder. The collected powder was washed with chloroform to give 3-chloro-pyridin-2-carboxylic acid (5-iodo-2-methylamino-pyridin-3-yl)-amide (3.6 g), which is hereinafter referred to as “intermediate compound (M20-7)”.

후처리

  1. filtrationthe mixture was filtered
  2. customto collect the precipitated powder
  3. washThe collected powder was washed with chloroform

출처 및 근거

ORD 기록
ord-5b5386473848492683f605376c221684
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353110B2

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