4-Hydroxybenzaldehyde → p-(Octyloxy)benzaldehyde

HRID 53099

반응식

HRID 53099 반응식
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1)=[O:2].Br[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:11]([O:9][C:6]1[CH:7]=[CH:8][C:3]([CH:1]=[O:2])=[CH:4][CH:5]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

참가 물질

5

반응물 3

HCID 1264-HydroxybenzaldehydeHCID 81401-BromooctaneHCID 11430Potassium Carbonate

생성물 1

HCID 90358p-(Octyloxy)benzaldehyde

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution containing 3.053 g (25 mmol) of 4-formylphenol, 6.48 ml (3705 mmol) of 1-bromooctane and 6.9 mg (50 mmol) of potassium carbonate in 100 ml of acetone was refluxed overnight. When the reaction was substantially complete, as indicated by thin layer chromatagraphy (TLC), the reaction was quenched by the addition of 100 ml of water. The desired compound was extracted from the reaction mixture using two 100 ml portions of diethyl ether. The resultant solution was dried over magnesium sulfate, filtered and then concentrated in vacuo to provide a liquid which was purified using HPLC (eluent of 10 ethyl acetate in hexane) to provide the desired compound.

후처리

  1. temperaturewas refluxed overnight
  2. customthe reaction was quenched by the addition of 100 ml of water
  3. extractionThe desired compound was extracted from the reaction mixture
  4. dry with materialThe resultant solution was dried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customto provide a liquid which
  8. customwas purified

출처 및 근거

ORD 기록
ord-bbd2d797dc224e55945d075f0efd3385
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05618787

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