(4,5-Dicyclopropyl-2-isopropoxyphenyl)methanol → 4,5-Dicyclopropyl-2-isopropoxybenzaldehyde

HRID 531029노트

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HRID 531029 반응식
[CH:1]1([C:4]2[C:9]([CH:10]3[CH2:12][CH2:11]3)=[CH:8][C:7]([CH2:13][OH:14])=[C:6]([O:15][CH:16]([CH3:18])[CH3:17])[CH:5]=2)[CH2:3][CH2:2]1>[O-2].[O-2].[Mn+4].C1(C)C=CC=CC=1>[CH:1]1([C:4]2[C:9]([CH:10]3[CH2:12][CH2:11]3)=[CH:8][C:7]([CH:13]=[O:14])=[C:6]([O:15][CH:16]([CH3:18])[CH3:17])[CH:5]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 90423712(4,5-Dicyclopropyl-2-isopropoxyphenyl)methanol

생성물 1

HCID 904237454,5-Dicyclopropyl-2-isopropoxybenzaldehyde수율 94.3%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 1140Toluene용매

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온도
80 °C

실험 절차

Manganese dioxide (14.7 g) was added at room temperature to a toluene (80 mL) solution of (4,5-dicyclopropyl-2-isopropoxyphenyl)methanol (5.22 g), and the mixture was stirred at 80° C. for 1 hour in a nitrogen atmosphere. The reaction mixture was filtered through celite, and then, the filtrate was concentrated. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (4.88 g).

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated
  3. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-c7b722ac0f184841bef005833c5135a5
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353108B2

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