Dimethylformamide → 2-Bromo-4'-fluoro-5-methoxybiphenyl-4-carbaldehyde

HRID 531048노트

반응식

HRID 531048 반응식
[Br:1]N1C(=O)NC(=O)N(Br)C1=O.CN(C=O)C.[F:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][C:27]([CH:30]=[O:31])=[C:26]([O:32][CH3:33])[CH:25]=2)=[CH:20][CH:19]=1>O>[Br:1][C:29]1[CH:28]=[C:27]([CH:30]=[O:31])[C:26]([O:32][CH3:33])=[CH:25][C:24]=1[C:21]1[CH:20]=[CH:19][C:18]([F:17])=[CH:23][CH:22]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 192912Dibromoisocyanuric acidHCID 225667274'-Fluoro-3-methoxy-[1,1'-biphenyl]-4-carbaldehyde

생성물 1

HCID 904235612-Bromo-4'-fluoro-5-methoxybiphenyl-4-carbaldehyde수율 180.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Dibromoisocyanuric acid (10.6 g) was added at 15° C. to 30° C. to a DMF (90 mL) solution of 4′-fluoro-3-methoxybiphenyl-4-carbaldehyde (16.0 g), and the mixture was stirred for 40 minutes. Then, water (30 mL) was added thereto, and the mixture was further stirred for 1 hour. The deposited solid was collected by filtration and washed with a mixed solution of DMF (15 mL) and water (15 mL) and water (30 mL) in this order to obtain the title compound (20.6 g).

후처리

  1. stirringthe mixture was further stirred for 1 hour
  2. filtrationThe deposited solid was collected by filtration
  3. washwashed with a mixed solution of DMF (15 mL) and water (15 mL) and water (30 mL) in this order

출처 및 근거

ORD 기록
ord-8b661be5d8f44d37bb8fe0c8b0d3bf69
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353108B2

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