4,5-Dicyclopropyl-2-ethoxybenzenemethanol → 4,5-Dicyclopropyl-2-ethoxybenzaldehyde

HRID 531055노트

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HRID 531055 반응식
[CH:1]1([C:4]2[C:9]([CH:10]3[CH2:12][CH2:11]3)=[CH:8][C:7]([CH2:13][OH:14])=[C:6]([O:15][CH2:16][CH3:17])[CH:5]=2)[CH2:3][CH2:2]1>[O-2].[O-2].[Mn+4].C1(C)C=CC=CC=1>[CH:1]1([C:4]2[C:9]([CH:10]3[CH2:12][CH2:11]3)=[CH:8][C:7]([CH:13]=[O:14])=[C:6]([O:15][CH2:16][CH3:17])[CH:5]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 904239324,5-Dicyclopropyl-2-ethoxybenzenemethanol

생성물 1

HCID 904236504,5-Dicyclopropyl-2-ethoxybenzaldehyde수율 95.2%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 1140Toluene용매

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온도
80 °C

실험 절차

Manganese dioxide (8.50 g) was added at room temperature to a toluene (50 mL) solution of (4,5-dicyclopropyl-2-ethoxyphenyl)methanol (2.84 g) in a nitrogen atmosphere, and the mixture was stirred at 80° C. for 1 hour. The reaction mixture was filtered through celite, and then, the filtrate was concentrated. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (2.68 g).

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated
  3. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-77514b2c7a8641898ea80573a13b4059
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09353108B2

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