Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 531395생성일: 2026년 10월 26일
4-Hydroxybenzophenone → (4-{[3-(Hydroxymethyl)oxetan-3-yl]methoxy}phenyl)(phenyl)methanone
https://huagongshe.com/reaction/531395
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Hydroxybenzophenone | HCID 14347 | — |
| 반응물 | 2,2-Bis(bromomethyl)-1,3-propanediol | HCID 18692 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | [3-(Bromomethyl)oxetan-3-yl]methanol | HCID 529264 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (4-{[3-(Hydroxymethyl)oxetan-3-yl]methoxy}phenyl)(phenyl)methanone | HCID 89906737 | — |
반응 단계
Dissolve 4-hydroxybenzophenone in anhydrous THF and treat it with equimolar quantity of sodium hydride at 0° C. for 2 h. Stir and warm the suspension to 50° C. and treat it with an equimolar quantity of 3-Bromomethyl-3-hydroxymethyloxetane (readily prepared in one step by method described in U.S. Pat. No. 5,489,700 or Tet. Lett. 2011, 52, p. 565-567 from commercially available 2,2-bis-(bromomethyl)propane-1,3-diol). Stir overnight at 50° C., filter the reaction mixture, evaporate the filtrate to dryness and purify the residue by column chromatography to provide (4-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}phenyl)(phenyl)methanone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09353211B2 |
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| 출처 데이터셋 | uspto-grants-2016_05 |
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| ORD ID | ord-96ea51ed7379461cb89c0e2a7f1e00f0 |
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| 출처 메모 | uspto-grants-2016_05 |
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