1-(Piperazin-1-yl)propan-1-one → 1,1-Dicyclohexyl-3-[5-(4-propionyl-piperazin-1-ylmethyl)-thiazol-2-yl]-urea

HRID 531976

반응식

HRID 531976 반응식
[CH:1]1([N:7]([CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[C:8]([NH:10][C:11]2[S:12][C:13]([CH:16]=O)=[CH:14][N:15]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N:24]1([C:30](=[O:33])[CH2:31][CH3:32])[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C(O)(=O)C>[CH:18]1([N:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:8]([NH:10][C:11]2[S:12][C:13]([CH2:16][N:27]3[CH2:28][CH2:29][N:24]([C:30](=[O:33])[CH2:31][CH3:32])[CH2:25][CH2:26]3)=[CH:14][N:15]=2)=[O:9])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1

참가 물질

5

반응물 3

HCID 38443751-(Piperazin-1-yl)propan-1-oneHCID 5049666Sodium triacetoxyborohydrideHCID 578834711,1-Dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

생성물 1

HCID 578837291,1-Dicyclohexyl-3-[5-(4-propionyl-piperazin-1-ylmethyl)-thiazol-2-yl]-urea수율 15%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (60 mg, 0.18 mmol), 1-piperazinyl-1-propanone (39 mg, 0.22 mmol), catalytic acetic acid and sodium triacetoxyborohydride (47 mg, 0.22 mmol) to afford 12 mg (15%) of the desired product after purification.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-51f61009edd74cacbc4240528d735566
출처 데이터셋
uspto-grants-2014_10
특허 번호
USRE045183E1

연결된 노트

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