HCID 61776502, 화합물 → 3-[2-(3-Cyclobutyl-3-cycloheptyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid

HRID 532013노트

반응식

HRID 532013 반응식
C(OC(=O)[CH:5]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([CH:21]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[CH:17]2[CH2:20][CH2:19][CH2:18]2)=[O:15])=[N:10][CH:9]=1)[CH3:6])C.C1(NC2CCC2)CCCCCC1.NC1SC=NC=1.C([O:49][C:50](=[O:53])CS)C>>[CH:17]1([N:16]([CH:21]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][CH2:5][CH2:6][C:50]([OH:53])=[O:49])=[CH:9][N:10]=2)[CH2:20][CH2:19][CH2:18]1

참가 물질

4

반응물 3

HCID 61776502HCID 61776502, 화합물HCID 866111945-Aminothiazole 2-mercaptoacetic acid ethyl esterHCID 86611211HCID 86611211, 화합물

생성물 1

HCID 578837153-[2-(3-Cyclobutyl-3-cycloheptyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid

실험 절차

[2-(3-Cycloheptyl-3-cyclobutyl-ureido)-thiazol-5-ylsulfanyl]-propionic acid ethyl ester prepared as described in general procedure (A) using cycloheptyl-cyclobutylamine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound

후처리

  1. customHydrolysis

출처 및 근거

ORD 기록
ord-e70b26928a044ac08110537a50029439
출처 데이터셋
uspto-grants-2014_10
특허 번호
USRE045183E1

반응 노트

불러오는 중…