Phosgene → Methyl 2-[(chlorocarbonyl)amino]benzoate

HRID 53243

반응식

HRID 53243 반응식
[C:1]([O:10][CH3:11])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[C:12](Cl)([Cl:14])=[O:13]>ClCCl>[Cl:14][C:12]([NH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]([O:10][CH3:11])=[O:9])=[O:13]

참가 물질

4

반응물 2

HCID 6371PhosgeneHCID 8635Methyl Anthranilate

생성물 1

HCID 21821749Methyl 2-[(chlorocarbonyl)amino]benzoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of methyl anthranilate (6.0 g) in dichloromethane (50 ml) was added dropwise over 15 min to a 0° solution of phosgene (20% in toluene, 100 ml) in dichloromethane (50 ml) under a nitrogen atmosphere. After addition the resulting opaque solution was stirred at room temperature for 5 h before concentrating to dryness to give the title compound as a white solid (8.0 g), m.p. 80°-82°.

후처리

  1. additionAfter addition the resulting opaque solution
  2. concentrationbefore concentrating to dryness

출처 및 근거

ORD 기록
ord-8f81fb5f9c9b4d1785c3bf64f43bab1c
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05618827

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