Ethyl Acetate → 1-(2-(2-Methoxy-4-nitrophenoxy)ethyl)pyrrolidine

HRID 532433

반응식

HRID 532433 반응식
C(=O)([O-])[O-].[K+].[K+].[N+:7]([C:10]1[CH:11]=[C:12]([OH:18])[C:13]([O:16][CH3:17])=[CH:14][CH:15]=1)([O-:9])=[O:8].Cl.ClC[CH2:22][N:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1.[C:28](OCC)(=O)C>CN(C=O)C.O>[CH3:28][O:18][C:12]1[CH:11]=[C:10]([N+:7]([O-:9])=[O:8])[CH:15]=[CH:14][C:13]=1[O:16][CH2:17][CH2:22][N:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1

참가 물질

7

반응물 4

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 694712-Methoxy-5-nitrophenolHCID 816681-(2-Chloroethyl)pyrrolidine hydrochloride

생성물 1

HCID 179893551-(2-(2-Methoxy-4-nitrophenoxy)ethyl)pyrrolidine

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

Potassium carbonate (3.3 g) was added to a solution of 4-nitroguaiacol (1.0 g) and 1-(2-chloroethyl)pyrrolidine hydrochloride (1.0 g) in DMF (20.0 mL), and the mixture was heated at 100° C. overnight. The reaction mixture was then mixed with ethyl acetate and water, and the organic phase was washed twice with water, dried over sodium sulfate and concentrated. The product with the molecular weight of 266.3 (C13H18N2O4) was obtained in this way; MS (ESI): 267 (M+H+).

후처리

  1. washthe organic phase was washed twice with water
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated
  4. customThe product with the molecular weight of 266.3 (C13H18N2O4) was obtained in this way

출처 및 근거

ORD 기록
ord-25ff1ee11c9f40fc841bf714f6d2c747
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853208B2

연결된 노트

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