Potassium Carbonate → tert-butyl 4-(7-bromo-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)piperidine-1-carboxylate

To 7-bromo-4-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine (200 mg) obtained in Step 4-4 of Preparation Example 4, t-butyl 4-hydroxypiperidine-1-carboxylate (180 mg), K2CO3 (168 mg) and N,N-dimethylformamide (4 ml) were added, and stirred at 100° C. for 12 hours in a hermetically sealed reactor. The reaction mixture was cooled to room temperature, extracted with ethyl acetate and distilled water, and the organic layer thus obtained was washed with water and a saline solution. Subsequently, the washed organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the title compound.

1. additionwere added
2. temperatureThe reaction mixture was cooled to room temperature
3. extractionextracted with ethyl acetate
4. distillationdistilled water
5. customthe organic layer thus obtained
6. washwas washed with water
7. dry with materialSubsequently, the washed organic layer was dried over anhydrous sodium sulfate
8. concentrationconcentrated under reduced pressure

ORD 기록

ord-1842d083bfee42a190eadb7ea630c9e3

출처 데이터셋

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08853213B2