Triethylamine → 4-(1H-1,2,4-Triazol-1-yl)phenyl 1,1,1-trifluoromethanesulfonate

HRID 532500노트

반응식

HRID 532500 반응식
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=2)[CH:5]=[N:4][CH:3]=[N:2]1.C(N(CC)CC)C.[O:20](S(C(F)(F)F)(=O)=O)[S:21]([C:24]([F:27])([F:26])[F:25])(=O)=[O:22]>ClCCl>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([O:12][S:21]([C:24]([F:27])([F:26])[F:25])(=[O:22])=[O:20])=[CH:10][CH:11]=2)[CH:5]=[N:4][CH:3]=[N:2]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 67749Trifluoromethanesulfonic anhydrideHCID 1100644-(1,2,4-Triazol-1-yl)phenol

생성물 1

HCID 866131654-(1H-1,2,4-Triazol-1-yl)phenyl 1,1,1-trifluoromethanesulfonate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1.0 g of 4-[1,2,4]triazol-1-yl-phenol was dissolved in 10 ml of dichloromethane, and 1.72 ml of triethylamine was added thereto. 1.56 ml of Tf2O was added to the mixture and stirred for 5 hr. The reaction was terminated by using water, and the resulting mixture was extracted with dichloromethane, dried over anhydrous sodium sulfate, and concentrated under a reduced pressure to obtain the title compound.

후처리

  1. customThe reaction was terminated
  2. extractionthe resulting mixture was extracted with dichloromethane
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under a reduced pressure

출처 및 근거

ORD 기록
ord-0accd0b89165430a8f7a88ff3ae105a5
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853213B2

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