1-(3,4,5-Trimethoxyphenyl)-2-propyn-1-ol → 3-(2,4-Diaminopyrimidin-5-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-yn-1-ol

HRID 532986노트

반응식

HRID 532986 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5](I)=[CH:4][N:3]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:22]([OH:25])[C:23]#[CH:24])[CH:15]=[C:16]([O:20][CH3:21])[C:17]=1[O:18][CH3:19]>>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:24]#[C:23][CH:22]([C:14]2[CH:15]=[C:16]([O:20][CH3:21])[C:17]([O:18][CH3:19])=[C:12]([O:11][CH3:10])[CH:13]=2)[OH:25])=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 161103271-(3,4,5-Trimethoxyphenyl)-2-propyn-1-olHCID 161103355-Iodopyrimidine-2,4-diamine

생성물 1

HCID 161103393-(2,4-Diaminopyrimidin-5-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-yn-1-ol수율 78%

실험 절차

2,4-Diamino-5-iodopyrimidine (236 mg) was allowed to react with 1-(3,4,5-Trimethoxyphenyl)prop-2-yn-1-ol (444 mg) as per the general procedure to afford 3-(2,4-Diaminopyrimidin-5-yl)-1-(3,4,5-trimethoxyphenyl)-prop-2-yn-1-ol as a yellow powder (257 mg, 78%): Rf=0.12 (9:1, CHCl3:MeOH); mp=203-205° C.; 1H NMR (DMSO-d6) δ 7.84 (s, 1H), 6.83 (s, 2H), 6.34 (s, 2H), 6.01 (d, J) 5.6 Hz, 1H), 5.50 (d, J) 5.4 Hz, 1H), 3.78 (s, 6H), 3.65 (s, 3H); 13C NMR (DMSO-d6) δ 163.8, 162.3, 158.2, 152.7, 138.3, 136.7, 109.3, 103.6, 96.3, 79.3, 63.4, 60.0, 55.8; Anal. (C16H18N4O4) C, H, N.

출처 및 근거

ORD 기록
ord-7b37d4eab57346be81a1142ce6ba5a83
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853228B2

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