Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Ethyl 3-(3-(methylsulfonyloxy)propyl)-1h-indole-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | ethyl 3-(3-hydroxypropyl)-1H-indole-2-carboxylate | HCID 67316234 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Ethyl 3-(3-(methylsulfonyloxy)propyl)-1h-indole-2-carboxylate | HCID 87353567 | — |
반응 단계
To a mixture of EXAMPLE 3A (0.125 g) and triethylamine (0.21 mL) in acetonitrile (3 mL) at 0-5° C. was added methanesulfonyl chloride (0.0404 mL). After 30 minutes, the mixture was concentrated, and the concentrate was purified by flash chromatography on silica gel with 0-30% ethyl acetate/hexanes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08853209B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-22d6a533025f46338385244e57eb3a97 |
| 출처 메모 | uspto-grants-2014_10 |