Triethylamine → HCID 59580742, 화합물
반응식
[Cl:1][C:2]1[S:3][C:4]([C:8]([OH:10])=O)=[C:5]([Cl:7])[N:6]=1.CCN(CC)CC.C1(P([N:32]=[N+:33]=[N-:34])(C2C=CC=CC=2)=O)C=CC=CC=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[S:3][C:4]([C:8]([N:32]=[N+:33]=[N-:34])=[O:10])=[C:5]([Cl:7])[N:6]=1참가 물질
5
실험 절차
To a solution of 2,4-dichloro-thiazole-5-carboxylic acid (1.98 g, 10 mmol) in toluene (50 mL) was added Et3N (1.01 g, 10 mmol) followed by diphenyl phosphoryl azide (2.75 g, 10 mmol). The reaction mixture was stirred at room temperature for 20 h. The reaction mixture was concentrated in vacuo and purified by silica gel chromatography (0 to 100% ethyl acetate/hexanes) to afford product as a brown solid (1.82 g, 82%): 13C NMR (75 MHz, CDCl3) δ 163.33, 156.83, 143.94, 124.02.
후처리
- concentrationThe reaction mixture was concentrated in vacuo
- custompurified by silica gel chromatography (0 to 100% ethyl acetate/hexanes)
출처 및 근거
- ORD 기록
- ord-56c12fe2a90d4057ae13ed41371c70d6
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08853246B2
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