Potassium Hydroxide → 5-tert-Butylaminocarbonyl-2-methylthiothiazole-4-carboxylic acid

HRID 5334

반응식

HRID 5334 반응식
[OH-].[K+].[C:3]([NH:7][C:8]([C:10]1[S:14][C:13]([S:15][CH3:16])=[N:12][C:11]=1[C:17]([O:19]CC)=[O:18])=[O:9])([CH3:6])([CH3:5])[CH3:4]>O.O.C(O)C>[C:3]([NH:7][C:8]([C:10]1[S:14][C:13]([S:15][CH3:16])=[N:12][C:11]=1[C:17]([OH:19])=[O:18])=[O:9])([CH3:6])([CH3:4])[CH3:5]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 150095734-Ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide

생성물 1

HCID 150095705-tert-Butylaminocarbonyl-2-methylthiothiazole-4-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매HCID 19096565Water ethanol용매

실험 절차

0.82 g (14.6 mmol) of potassium hydroxide in 10 ml of water was added to a solution of 4.00 g (13.2 mmol) of 4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide in 50 ml of water/ethanol (2:1), and the mixture was refluxed for 2 hours. The solvent mixture was then removed under reduced pressure and the residue was taken up in 50 ml of water and acidified with concentrated hydrochloric acid. The precipitated product was filtered off and dried.

후처리

  1. temperaturethe mixture was refluxed for 2 hours
  2. customThe solvent mixture was then removed under reduced pressure
  3. filtrationThe precipitated product was filtered off
  4. customdried

출처 및 근거

ORD 기록
ord-2edd7bfaf0f643ea9042f3b3d6c043f5
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244867

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