Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 533460생성일: 2026년 10월 25일
p-Toluenesulfonic acid → 2-(3-acetamidophenylamino)-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxamide
https://huagongshe.com/reaction/533460
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | m-Aminoacetanilide | HCID 7604 | — |
| 반응물 | 2-(1H-benzo[d][1,2,3]triazol-1-yloxy)-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxamide | HCID 57472013 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 2-(3-acetamidophenylamino)-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxamide | HCID 58098914 | 32.1% |
반응 단계
To a solution of 2-(1H-benzo[d][1,2,3]triazol-1-yloxy)-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxamide (60 mg, 0.15 mmol) in NMP (0.6 mL) was added 3-acetamidoaniline (25 mg, 0.165 mmol) and pTsOH*H2O (28 mg, 0.15 mmol). The mixture was heated at 100° C. for 2 h, cooled to room temperature, purified by preparative HPLC to give 2-(3-acetamidophenylamino)-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxamide (20 mg). MS found for C22H21N7O2 as (M+H)+ 416.3. λ=211.3, 250.9.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08853230B2 |
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| 출처 데이터셋 | uspto-grants-2014_10 |
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| ORD ID | ord-429b95eb16ea414892a92dddbfaab550 |
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| 출처 메모 | uspto-grants-2014_10 |
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