Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → N-(5-nitro-2-(2-(pyrrolidin-1-yl)ethoxy)phenyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1-(2-Chloroethyl)pyrrolidine hydrochloride | HCID 81668 | — |
| 반응물 | Acetamide, N-(2-hydroxy-5-nitrophenyl)- | HCID 3292867 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(5-nitro-2-(2-(pyrrolidin-1-yl)ethoxy)phenyl)acetamide | HCID 58098809 | 33% |
반응 단계
To a solution of N-(2-hydroxy-5-nitrophenyl)acetamide (870 mg, 4.44 mmol) in DMF (5 mL) was added NaH (196 mg, 5.32 mmol) and K2CO3 (2.11 g, 13.32 mmol), followed by 1-(2-chloroethyl)pyrrolidine hydrochloride (905 mg, 5.32 mmol). After heating at 100° C. for 20h, the solution was poured to ice, and was extracted with EtOAc, organic layer was washed with Sat. NaHCO3, brine, dried and concentrated to give N-(5-nitro-2-(2-(pyrrolidin-1-yl)ethoxy)phenyl)acetamide (430 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08853230B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-8d1a65f1c54b4bc6b776dfccd7943cc4 |
| 출처 메모 | uspto-grants-2014_10 |