Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → Diisopropylethylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Propionic anhydride | HCID 31263 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Diisopropylethylamine | HCID 81531 | — |
반응 단계
The amide acid VIIC is cyclized by treatment with a cyclizing agent such as acetic anhydride or propionic anhydride (employing a molar ratio of anhydride:VIIC of within the range of from about 7:1 to about 5:1) and amine base such as triethylamine or diisopropylethylamine, in the presence of an inert organic solvent such as THF, toluene, monoglyme or ethylacetate, at a temperature within the range of from about 70° to about 110° C., to form compound XXVIII.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05618946 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-6d4ad5631c0b48418e89b9ef8300b1c7 |
| 출처 메모 | uspto-grants-1997_04 |