Methanol → 6-bromo-2-(2-ethylsulfinylphenyl)-3-methyl-3H-imidazo[4,5-b]pyridine

HRID 533609

반응식

HRID 533609 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[S:17][CH2:18][CH3:19])[N:8]([CH3:20])[C:5]2=[N:6][CH:7]=1.I([O-])(=O)(=O)=[O:22].[Na+].CO>O.C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[S:17]([CH2:18][CH3:19])=[O:22])[N:8]([CH3:20])[C:5]2=[N:6][CH:7]=1

참가 물질

6

반응물 3

HCID 887MethanolHCID 23667635Sodium periodateHCID 679820336-bromo-2-(2-ethylsulfanylphenyl)-3-methyl-3H-imidazo[4,5-b]pyridine

생성물 1

HCID 867082046-bromo-2-(2-ethylsulfinylphenyl)-3-methyl-3H-imidazo[4,5-b]pyridine수율 90.8%

시약·촉매·용매 2

HCID 962Water용매2회HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 6-bromo-2-(2-ethylsulfanylphenyl)-3-methyl-3H-imidazo[4,5-b]pyridine (0.20 g), sodium periodate (0.18 g), methanol (3 ml), water (1 ml), and THF (0.4 ml) was stirred at room temperature for 3.5 hours. Water was poured thereinto under ice-cooling, and then the precipitated solid was collected by filtration. The obtained solid was washed with water and hexane, and dried to give 0.19 g of 6-bromo-2-(2-ethylsulfinylphenyl)-3-methyl-3H-imidazo[4,5-b]pyridine (hereinafter referred to as Present Compound 43).

후처리

  1. temperatureunder ice-cooling
  2. filtrationthe precipitated solid was collected by filtration
  3. washThe obtained solid was washed with water and hexane
  4. customdried

출처 및 근거

ORD 기록
ord-349e825d2bba4fcabfbe3ec47462122a
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853238B2

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