Aluminium lithium hydride → 3-(3-methoxy-phenyl)-N,N,2-trimethyl pentylamine

HRID 533681노트

반응식

HRID 533681 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][N:8]([CH3:24])[C:9](=O)[CH:10]([CH3:22])[CH:11]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=1)[CH2:12][CH3:13]>CCOCC>[CH3:21][O:20][C:16]1[CH:15]=[C:14]([CH:11]([CH2:12][CH3:13])[CH:10]([CH3:22])[CH2:9][N:8]([CH3:24])[CH3:7])[CH:19]=[CH:18][CH:17]=1

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 67306944Benzenepropanamide, beta-ethyl-3-methoxy-N,N,alpha-trimethyl-

생성물 1

HCID 223770203-(3-methoxy-phenyl)-N,N,2-trimethyl pentylamine수율 85%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

The steps are: add anhydrous ether into a reaction flask, and add lithium aluminum hydride under the condition of ice bath; dip compound 7, control the temperature within 10, after the dipping detect the reaction process by TLC; after the reaction is ended, pour the reaction liquid in the ice water slowly, separate the ether layer out, rinse by water, perform drying, and recycle the solvent by decompression to obtain a light yellow liquid, 3-(3-methoxy-phenyl)-N,N,2-trimethyl pentylamine. Yield: 85%.

후처리

  1. additionpour
  2. customseparate the ether layer out,
  3. washrinse by water
  4. customperform drying

출처 및 근거

ORD 기록
ord-674a2d66e96a4881858494af3ccc1fb6
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853393B2

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