1-(3-Bromopropoxy)-2-fluorobenzene → 1-{3-[(2-Fluorophenyl)oxy]propyl}-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide

HRID 533844노트

반응식

HRID 533844 반응식
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[F:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[O:30][CH2:31][CH2:32][CH2:33][Br:34]>CC#N>[Br-:34].[F:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[O:30][CH2:31][CH2:32][CH2:33][N+:1]12[CH2:6][CH2:5][C:4]([C:9]([OH:10])([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)([CH2:3][CH2:2]1)[CH2:7][CH2:8]2

참가 물질

4

반응물 2

HCID 71722931-(3-Bromopropoxy)-2-fluorobenzeneHCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

생성물 1

HCID 115409861-{3-[(2-Fluorophenyl)oxy]propyl}-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide수율 68.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0282 g, 0.0960 mmol) and 3-bromopropyl 2-fluorophenyl ether (0.0274 g, 0.118 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0345 g, 68.3%). EI-MS m/z 446(M+) Rt (1.96 min).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-2510b6ecfa574f7dbb19393f7c5678a3
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853404B2

반응 노트

불러오는 중…