1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol → 3-{[3-(Diethylamino)phenyl]oxy}propyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide

HRID 533858노트

반응식

HRID 533858 반응식
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:23][CH2:24][CH2:25][CH2:26][O:27][C:28]1[CH:29]=[C:30]([CH:36]=[CH:37][CH:38]=1)[N:31]([CH2:34][CH3:35])[CH2:32][CH3:33]>CC#N>[Br-:23].[CH2:34]([N:31]([CH2:32][CH3:33])[C:30]1[CH:29]=[C:28]([O:27][CH2:26][CH2:25][CH2:24][N+:1]23[CH2:6][CH2:5][C:4]([C:9]([OH:10])([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=4)([CH2:3][CH2:2]2)[CH2:7][CH2:8]3)[CH:38]=[CH:37][CH:36]=1)[CH3:35]

참가 물질

4

반응물 2

HCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanolHCID 689633743-[(3-bromopropyl)oxy]-N,N-diethylaniline

생성물 1

HCID 115343583-{[3-(Diethylamino)phenyl]oxy}propyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide수율 63%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0257 g, 0.0876 mmol) and 3-[(3-bromopropyl)oxy]-N,N-diethylaniline (0.0314 g, 0.110 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.032.0 g, 63.0%). EI-MS m/z 500(M+) Rt (1.58 min).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-1c7a14e4af784ca18be9e12e66cf9e96
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853404B2

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