6-Bromo-4-fluoro-2,3-dihydro-1H-inden-1-one → (R)-3-[6-(2-Cyclopropyl-ethoxy)-pyridin-3-yloxv]-1-(7-fluoro-3-oxo-indan-5-yl)-pyrrolidin-2-one
반응식
[CH:1]1([CH2:4][CH2:5][O:6][C:7]2[N:12]=[CH:11][C:10]([O:13][C@@H:14]3[CH2:18][CH2:17][NH:16][C:15]3=[O:19])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.Br[C:21]1[CH:29]=[C:28]2[C:24]([CH2:25][CH2:26][C:27]2=[O:30])=[C:23]([F:31])[CH:22]=1>O1CCOCC1>[CH:1]1([CH2:4][CH2:5][O:6][C:7]2[N:12]=[CH:11][C:10]([O:13][C@@H:14]3[CH2:18][CH2:17][N:16]([C:21]4[CH:29]=[C:28]5[C:24](=[C:23]([F:31])[CH:22]=4)[CH2:25][CH2:26][C:27]5=[O:30])[C:15]3=[O:19])=[CH:9][CH:8]=2)[CH2:2][CH2:3]1참가 물질
4
반응 조건
- 온도
- 85 °C