(3S)-3-hydroxypyrrolidin-2-one → (R)-3-[4-(4-Fluoro-phenoxy)-phenoxy]-pyrrolidin-2-one

HRID 533896

반응식

HRID 533896 반응식
[OH:1][C@H:2]1[CH2:6][CH2:5][NH:4][C:3]1=[O:7].[F:8][C:9]1[CH:22]=[CH:21][C:12]([O:13][C:14]2[CH:19]=[CH:18][C:17](O)=[CH:16][CH:15]=2)=[CH:11][CH:10]=1>>[F:8][C:9]1[CH:22]=[CH:21][C:12]([O:13][C:14]2[CH:19]=[CH:18][C:17]([O:1][C@@H:2]3[CH2:6][CH2:5][NH:4][C:3]3=[O:7])=[CH:16][CH:15]=2)=[CH:11][CH:10]=1

참가 물질

3

반응물 2

HCID 11029774(3S)-3-hydroxypyrrolidin-2-oneHCID 129406244-(4-Fluorophenoxy)phenol

생성물 1

HCID 86715089(R)-3-[4-(4-Fluoro-phenoxy)-phenoxy]-pyrrolidin-2-one

실험 절차

Typical Procedure 3 was followed. Reaction of (S)-3-hydroxy-pyrrolidin-2-one with 4-(4-fluoro-phenoxy)-phenol provided the title compound. MS ESI+: m/z=288 [M+H]+.

출처 및 근거

ORD 기록
ord-73298a10c0974ccc9d833d5470ff1f2b
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853412B2

연결된 노트

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