4-Phenoxyphenol → (R)-3-[4-(Phenoxy)-phenoxy]-pyrrolidi n-2-one

반응식

[OH:1][C@H:2]1[CH2:6][CH2:5][NH:4][C:3]1=[O:7].[O:8]([C:15]1[CH:20]=[CH:19][C:18](O)=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[O:8]([C:15]1[CH:16]=[CH:17][C:18]([O:1][C@@H:2]2[CH2:6][CH2:5][NH:4][C:3]2=[O:7])=[CH:19][CH:20]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

반응물 2

HCID 132544-Phenoxyphenol

HCID 11029774(3S)-3-hydroxypyrrolidin-2-one

생성물 1

HCID 86715090(R)-3-[4-(Phenoxy)-phenoxy]-pyrrolidi n-2-one

실험 절차

Typical Procedure 3 was followed. Reaction of (S)-3-hydroxy-pyrrolidin-2-one with 4-(phenoxy)-phenol provided the title compound. MS ESI+: m/z=270 [M+H]+.

출처 및 근거

ORD 기록: ord-9a555a97c31c4cd296f759017ea05189
출처 데이터셋: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08853412B2

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