참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 5-Hydroxypyridine-2-carboxylic acid | HCID 268740 | — |
| 반응물 | HCID 178449908 | HCID 178449908 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 6-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-ol | HCID 136377300 | — |
반응 단계
To DMSO (25 mL) was added 5-hydroxy-pyridine-2-carboxylic acid (1.0 g) and CDI (1.3 g). After 15 minutes N-hydroxy-isobutyramidine (820 mg) was added. After 1 hour the mixture was heated to 90° C. for 1 hour. After the mixture reached room temperature, it was diluted with EA and washed three times with HCl (0.1 M). The organic phase was dried (Na2SO4) and concentrated to provide the title compound. MS ESI+: m/z=206 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08853412B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_10 |
|---|
| ORD ID | ord-989f920584734f61b7577085f4131722 |
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| 출처 메모 | uspto-grants-2014_10 |
|---|
