Cyclopropanemethanol → 5-Bromo-2-(cyclopropylmethoxy)-3-fluoropyridine

반응식

[Br:1][C:2]1[CH:3]=[C:4]([F:9])[C:5](F)=[N:6][CH:7]=1.[CH:10]1([CH2:13][OH:14])[CH2:12][CH2:11]1>>[Br:1][C:2]1[CH:3]=[C:4]([F:9])[C:5]([O:14][CH2:13][CH:10]2[CH2:12][CH2:11]2)=[N:6][CH:7]=1

참가 물질

반응물 2

HCID 75644Cyclopropanemethanol

HCID 145496545-Bromo-2,3-difluoropyridine

생성물 1

HCID 867151175-Bromo-2-(cyclopropylmethoxy)-3-fluoropyridine

실험 절차

Following Typical Procedure 6, reaction of 5-bromo-2,3-difluoro-pyridine with cyclopropyl-methanol provided the subtitle compound. MS ESI+: m/z=246 [M+H]+.

출처 및 근거

ORD 기록: ord-667d431be3df480485687dff0fefd7da
출처 데이터셋: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08853412B2

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