Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Anisoyl chloride → N-(4,5-Diphenyl-thiazol-2-yl)-4-methoxy-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Anisoyl chloride | HCID 7477 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Amino-4,5-diphenylthiazole | HCID 73222 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | N-(4,5-Diphenyl-thiazol-2-yl)-4-methoxy-benzamide | HCID 3112498 | — |
반응 단계
4,5-Diphenyl-thiazol-2-ylamine (50.5 mg, 0.200 mmol) and 4-methoxy-benzoyl chloride (34.1 mg, 0.200 mmol) were dissolved in 1,4-dioxane (2 mL) containing triethylamine (84.1 μL, 0.600 mmol). The reaction mixture was stirred overnight at room temperature. The crude product was filtered, evaporated to dryness, dissolved in 1 mL of dimethylsulfoxide and purified by reverse-phase preparative liquid chromatography (12.5 mg, 0.0323 mmol, 16.2%). ESI-MS m/z calc. 386.1. found 387.2 (M+1)+ Retention time 3.95 minutes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08853415B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-44c566a4a2bd4a8b9d8466a6a9483ef4 |
| 출처 메모 | uspto-grants-2014_10 |