Water → HCID 86644151, 화합물
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[C:1]([O:4][C:5]1[C:6]([C:11]#[C:12][Si](C)(C)C)=[N:7][CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2].O.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>C1COCC1>[C:1]([O:4][C:5]1[C:6]([C:11]#[CH:12])=[N:7][CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2]참가 물질
5
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- 온도
- 0 °C
실험 절차
To a solution of 2-((trimethylsilyl)ethynyl)pyridin-3-yl acetate (9.5 g, 41 mmol) in THF (200 mL) was added water (25 ml). The reaction was cooled to 0° C. and TBAF (1M, 45 ml, 45 mmol) was added. The mixture warmed to ambient temperature and stirred for 1 hour. Water (100 mL) was added and the volume was reduced by half. The product was extracted into ether (3×100 mL), washed with brine and dried over MgSO4. The solution was concentrated in vacuo to afford 2-ethynylpyridin-3-yl acetate (5.5 g, 34 mmol) as a light brown oil.
후처리
- temperatureThe mixture warmed to ambient temperature
- extractionThe product was extracted into ether (3×100 mL)
- washwashed with brine
- dry with materialdried over MgSO4
- concentrationThe solution was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-1143f189375f465ba33865db297f8727
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08853409B2
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