Methyl 2-fluoro-3-nitrobenzoate → Methyl 3-amino-2-fluorobenzoate hydrochloride

HRID 534665노트

반응식

HRID 534665 반응식
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-])=O)[C:5]=1[F:13].[ClH:15].CO>[Pd].CO>[ClH:15].[NH2:10][C:6]1[C:5]([F:13])=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([O:2][CH3:1])=[O:14]

참가 물질

5

반응물 2

HCID 13470961Methyl 2-fluoro-3-nitrobenzoateHCID 21893726Hydrochloride methanol

생성물 1

HCID 67167731Methyl 3-amino-2-fluorobenzoate hydrochloride수율 85%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

2-Fluoro-3-nitrobenzoic acid methyl ester (9.10 g, 0.046 mol), 10% hydrochloric acid/methanol (25 ml), methanol (60 ml), and 5% palladium/carbon (50% wet product) (2.7 g) were introduced, and the reaction mixture was hydrogenated at room temperature. After completion of the reaction, the catalyst was filtered away, and the filtrate was concentrated under reduced pressure. The concentration residue was washed with diisopropyl ether, as a result of which 8.01 g (yield: 85%) of the indicated compound was obtained.

후처리

  1. customwas hydrogenated at room temperature
  2. customAfter completion of the reaction
  3. filtrationthe catalyst was filtered away
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. washThe concentration residue was washed with diisopropyl ether

출처 및 근거

ORD 기록
ord-4ca83f54d0934a93b6ccb7a2892b52c0
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853440B2

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