Thionyl Chloride → 6-(3-Fluorophenyl)-3-pyridinecarbonyl chloride

HRID 534742노트

반응식

HRID 534742 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[CH:12][C:11]([C:14]([OH:16])=O)=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.S(Cl)([Cl:19])=O>O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[CH:12][C:11]([C:14]([Cl:19])=[O:16])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 247299726-(3-Fluorophenyl)nicotinic acid

생성물 1

HCID 866181106-(3-Fluorophenyl)-3-pyridinecarbonyl chloride수율 99.3%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

6-(3-Fluorophenyl)-3-pyridinecarboxylic acid (82 mg, 0.376 mmol) was stirred in dioxane (4 mL) and thionyl chloride (0.137 mL, 1.88 mmol) added dropwise. The reaction mixture was heated at reflux for 40 min then concentrated in vacuo to give 6-(3-fluorophenyl)-3-pyridinecarbonyl chloride as a white solid (0.088 g) which was used directly in step 2.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 40 min
  3. concentrationthen concentrated in vacuo

출처 및 근거

ORD 기록
ord-c4505d7185bb43ecbb62bf048c82df5f
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08853218B2

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