(3-Chloro-5-(trifluoromethyl)phenyl)methanol → [3-Bromo-5-(trifluoromethyl)phenyl]methanol

반응식

[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)[C:5](OC)=[O:6].ClC1C=C(CO)C=C(C(F)(F)F)C=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:5][OH:6])[CH:9]=[C:10]([C:12]([F:14])([F:15])[F:13])[CH:11]=1

참가 물질

반응물 2

HCID 3857254(3-Chloro-5-(trifluoromethyl)phenyl)methanol

HCID 18942156Methyl 3-bromo-5-(trifluoromethyl)benzoate

생성물 1

HCID 29919767[3-Bromo-5-(trifluoromethyl)phenyl]methanol수율 35%

실험 절차

The title compound was prepared from methyl 3-bromo-5-(trifluoromethyl)benzoate (Reference Example 37) by a procedure similar to the one described for (3-chloro-5-(trifluoromethyl)phenyl)methanol (Reference Example 30) to provide (3-bromo-5-(trifluoromethyl)phenyl)methanol (7.42 g, 35% (2 steps)) as a yellow oil.

출처 및 근거

ORD 기록: ord-e6c46743bfe84d0ca0ba5b422a1fe056
출처 데이터셋: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08853215B2

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