2-Chloronicotinoyl chloride → N-(2-Bromo-6-methoxy-3-pyridinyl)-2-chloro-3-pyridinecarboxamide

HRID 53523

반응식

HRID 53523 반응식
[NH2:1][C:2]1[C:3]([Br:10])=[N:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1.[Cl:11][C:12]1[N:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14](Cl)=[O:15]>C(Cl)Cl.N1C=CC=CC=1>[Br:10][C:3]1[C:2]([NH:1][C:14]([C:13]2[C:12]([Cl:11])=[N:20][CH:19]=[CH:18][CH:17]=2)=[O:15])=[CH:7][CH:6]=[C:5]([O:8][CH3:9])[N:4]=1

참가 물질

5

반응물 2

HCID 27745412-Chloronicotinoyl chlorideHCID 152093242-Bromo-6-methoxypyridin-3-amine

생성물 1

HCID 10617311N-(2-Bromo-6-methoxy-3-pyridinyl)-2-chloro-3-pyridinecarboxamide수율 95.7%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 3-amino-2-bromo-6-methoxypyridine (2.7 g) in methylene chloride (20 ml) and pyridine (1 ml) was added 2-chloronicotinoyl chloride (2.2 g), and the resulting mixture was stirred 20 min. The mixture was then diluted with methylene chloride (100 ml), washed with water (100 ml), dried (anhydrous magnesium sulfate), and concentrated. The semisolid residue was saturated with hexane, filtered, and dried to give 4.1 g of product suitable for use in the next reaction.

후처리

  1. washwashed with water (100 ml)
  2. dry with materialdried (anhydrous magnesium sulfate)
  3. concentrationconcentrated
  4. filtrationfiltered
  5. customdried

출처 및 근거

ORD 기록
ord-ab68f65f49af453c8471dd3e1e060b1a
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05620974

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