6-Benzyl-N-(6-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine → N-(6-(Trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

HRID 535352노트

반응식

HRID 535352 반응식
C([N:8]1[CH2:28][CH2:27][C:11]2[N:12]=[CH:13][N:14]=[C:15]([NH:16][C:17]3[CH:18]=[N:19][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:21][CH:22]=3)[C:10]=2[CH2:9]1)C1C=CC=CC=1>CO.[OH-].[Pd+2].[OH-]>[F:25][C:23]([F:24])([F:26])[C:20]1[N:19]=[CH:18][C:17]([NH:16][C:15]2[C:10]3[CH2:9][NH:8][CH2:28][CH2:27][C:11]=3[N:12]=[CH:13][N:14]=2)=[CH:22][CH:21]=1

참가 물질

4

반응물 1

HCID 593465456-Benzyl-N-(6-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

생성물 1

HCID 59346451N-(6-(Trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

6-Benzyl-N-(6-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine (1.7 g, 4.4 mmol) was dissolved in methanol (25 mL) and palladium hydroxide was added (0.2 g, 20% wt). The mixture was shaken on a Parr Shaker under H2(g) atmosphere (60 PSI) for 1 day. The mixture was filtered through celite and evaporated to give 1.3 g (quant.) as an orange oil, which was used as such for the next step.

후처리

  1. filtrationThe mixture was filtered through celite
  2. customevaporated
  3. customto give 1.3 g (quant.) as an orange oil, which

출처 및 근거

ORD 기록
ord-4c90976e343f4f50b920b3740a48f68e
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859545B2

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