Trifluoroacetic acid methylene chloride → N-[6-amino-2-(2-phenylethynyl)pyridin-3-yl]oxane-4-carboxamide

HRID 535398노트

반응식

HRID 535398 반응식
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]([CH:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[O:16])=[C:10]([C:23]#[C:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:9]=1)(C)(C)C.C(Cl)Cl.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][C:8]1[N:9]=[C:10]([C:23]#[C:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:11]([NH:14][C:15]([CH:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[O:16])=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 86694378tert-butyl-N-[5-(oxane-4-carbonylamino)-6-(2-phenylethynyl)pyridin-2-yl]-carbamate

생성물 1

HCID 86694381N-[6-amino-2-(2-phenylethynyl)pyridin-3-yl]oxane-4-carboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of tert-butyl-N-[5-(oxane-4-carbonylamino)-6-(2-phenylethynyl)pyridin-2-yl]-carbamate C5b (29 mg, 0.07 mmol) and DCM:TFA (9:1, 3 ml) is stirred at RT for 2 h. The mixture is diluted with DCM and extracted with a saturated aqueous solution of NaHCO3.

후처리

  1. extractionextracted with a saturated aqueous solution of NaHCO3

출처 및 근거

ORD 기록
ord-5d3d5202a1ba4bc08e031798e087f841
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859541B2

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