Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 53543생성일: 2026년 10월 23일
4-Hydroxypyrrolidine → 11-Ethyl-2-(3-hydroxypyrrolidin-1-yl)-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one
https://huagongshe.com/ko/reaction/53543
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Hydroxypyrrolidine | HCID 98210 | — |
| 반응물 | Dipyridodiazepinone deriv. 15 | HCID 463144 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 11-Ethyl-2-(3-hydroxypyrrolidin-1-yl)-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one | HCID 463549 | — |
반응 단계
A suspension of the 2-chloro-5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (0.14 g) in 3-hydroxypyrrolidine (0.29 g) in an open test tube was heated at 170° C. for 30 minutes. After cooling to room temperature the mixture was diluted with water and extracted with ethyl acetate. The organic phase was washed, dried, and evaporated. Chromatography over silica gel with ethyl acetate gave the title compound, which crystallized from ethyl acetate. Yield, 0.12 g, m.p. 131°-134° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05620974 |
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| 출처 데이터셋 | uspto-grants-1997_04 |
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| ORD ID | ord-85aae3c011414557809e137dd866b50d |
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| 출처 메모 | uspto-grants-1997_04 |
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