Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dipyridodiazepinone deriv. 15 → 5,11-Dihydro-11-ethyl-2-[(S)-2-(hydroxymethyl)pyrrolidin-1-yl]-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dipyridodiazepinone deriv. 15 | HCID 463144 | — |
| 반응물 | L-Prolinol | HCID 640091 | — |
| 생성물 | 5,11-Dihydro-11-ethyl-2-[(S)-2-(hydroxymethyl)pyrrolidin-1-yl]-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one | HCID 54501305 | — |
반응 단계
The title compound, m.p. 238°-240° C., was synthesized from 2-chloro-5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and (S)-(+)-2-pyrrolidinemethanol using procedures analogous to those described above, except that the mixture was heated in a pressure bottle at 170° C. for 3 hrs, and the product was crystallized from chloroform/hexane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05620974 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-de8470827a18435282663146f3233ced |
| 출처 메모 | uspto-grants-1997_04 |