반응식
Cl[C:2]1[CH:3]=[C:4]([CH3:20])[C:5]2[NH:6][C:7](=[O:19])[C:8]3[CH:18]=[CH:17][CH:16]=[N:15][C:9]=3[N:10]([CH2:13][CH3:14])[C:11]=2[N:12]=1.[NH:21]1[CH2:25][CH2:24][CH2:23][C@@H:22]1[CH2:26][OH:27]>>[CH2:13]([N:10]1[C:9]2[N:15]=[CH:16][CH:17]=[CH:18][C:8]=2[C:7](=[O:19])[NH:6][C:5]2[C:4]([CH3:20])=[CH:3][C:2]([N:21]3[CH2:25][CH2:24][CH2:23][C@@H:22]3[CH2:26][OH:27])=[N:12][C:11]1=2)[CH3:14]참가 물질
3
실험 절차
The title compound, m.p. 239°-242° C., was synthesized from 2-chloro-5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and (R)-(-)-2-pyrrolidinemethanol using procedures analogous to those described above, except that the mixture was heated in a pressure bottle at 160°-170° C. for 2 hrs, and the product was crystallized from chloroform/hexane.
출처 및 근거
- ORD 기록
- ord-080ed352435f45338c219a3be991ad6a
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05620974
연결된 노트
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