Ethanolamine → Dipyridodiazepinone deriv. 23

반응식

Cl[C:2]1[CH:3]=[C:4]([CH3:20])[C:5]2[NH:6][C:7](=[O:19])[C:8]3[CH:18]=[CH:17][CH:16]=[N:15][C:9]=3[N:10]([CH2:13][CH3:14])[C:11]=2[N:12]=1.[CH2:21]([CH2:23][NH2:24])[OH:22]>>[CH2:13]([N:10]1[C:9]2[N:15]=[CH:16][CH:17]=[CH:18][C:8]=2[C:7](=[O:19])[NH:6][C:5]2[C:4]([CH3:20])=[CH:3][C:2]([NH:24][CH2:23][CH2:21][OH:22])=[N:12][C:11]1=2)[CH3:14]

참가 물질

반응물 2

HCID 700Ethanolamine

HCID 463144Dipyridodiazepinone deriv. 15

생성물 1

HCID 463150Dipyridodiazepinone deriv. 23

실험 절차

The title compound, m.p. 241°-244° C., was synthesized from 2-chloro-5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and ethanolamine using procedures analogous to those described above, except that the mixture was heated in a pressure bottle at 260° C. for 50 min., and the product was crystallized from chloroform/ethanol.

출처 및 근거

ORD 기록: ord-188b5b5854db42b897e43c3abfb0c01f
출처 데이터셋: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05620974

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