(4-Chlorophenyl)acetic acid → HCID 70975926, 화합물

HRID 535488노트

반응식

HRID 535488 반응식
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:17].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26](O)=[O:27])=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[S:13][CH:14]=[CH:15][CH:16]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:17])=[O:27])=[CH:21][CH:20]=1

참가 물질

3

반응물 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 70975803HCID 70975803, 화합물

생성물 1

HCID 70975926HCID 70975926, 화합물

실험 절차

The product of Example 10B and 2-(4-chlorophenyl)acetic acid were treated using a method similar to that described in Example 10C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.73 (s, 1H), 8.40 (ddd, J=7.7, 1.6, 0.8 Hz, 1H), 8.17 (ddd, J=8.1, 1.3, 0.6 Hz, 1H), 8.04 (ddd, J=8.0, 7.2, 1.6 Hz, 1H), 7.98 (ddd, J=7.8, 7.2, 1.3 Hz, 1H), 7.81 (dd, J=5.1, 1.1 Hz, 1H), 7.65 (dd, J=3.6, 1.1 Hz, 1H), 7.35-7.47 (m, 4H), 7.28 (dd, J=5.1, 3.6 Hz, 1H), 3.72 (s, 2H); MS (APCI) M/Z 396 (M+H)+.

출처 및 근거

ORD 기록
ord-f9102ff5715b4af6a2eb28dcc65ffdc2
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859549B2

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